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KMID : 0351619660070020221
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Kyungpook Medical Journal
1966 Volume.7 No. 2 p.221 ~ p.230
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Experimental studies of Effects of Thymus on Vital Reaction to Cortisone and Carbon tetrachloride
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Abstract
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Vital reactions to cortisone and carbon tetrachloride in both thymectomized group and non-thymectomized group (control group) of young and adult rabbits were studied histopathotogically with the following results.
1) The body weight was decreased in both cortisone-administered and carbon tetrachloride-administered groups, but weight differences between the thymectomized group and the control group were not significant.
2) The histopathological changes of various organs resulting from the administration of massive doses of cortisone were more prominent in the thymectomized rabbits than those of the controls. However, no appreciable differences between young and adult rabbits were noted.
3) Hepatic degeneration, necrosis and fibrosis, resulting from administration of carton tetrachloride in the thymectomized young and adult rabbits were more marked than those in the control group. In the former group, histopathological changes such as increase of the hepatic glycogen, atrophy of the lymphoid tissues, decreased lipid in the adrenal cortices and atrophy of the thyroid glands were noted while the control group usually did not show such alterations. No remarkable difference between the young and adult rabbits was found.
4) Marked vital reactions to cortisone and carton tetrachloride were induced in the thymectomized rabbits and these effects of the thymus were noted in both young and adult rabbits.
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